2 2 2 Trifluoroacetic Acid
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2,2,2-Trifluoroacetic Acid

Shijie Chemical

    Specifications

    HS Code

    161682

    Name 2,2,2-Trifluoroacetic Acid
    Chemical Formula C2HF3O2
    Molar Mass 114.02 g/mol
    Appearance Colorless liquid
    Odor Pungent, acetic - like odor
    Density 1.489 g/cm³
    Melting Point -15.4 °C
    Boiling Point 72.4 °C
    Solubility In Water Miscible
    Pka 0.23
    Acidity Strong acid
    Vapor Pressure 33.3 hPa (20 °C)

    As an accredited 2,2,2-Trifluoroacetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250 - mL bottle of 2,2,2 - Trifluoroacetic Acid for chemical use.
    Storage 2,2,2 - Trifluoroacetic Acid should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly - sealed, corrosion - resistant container, preferably made of materials like glass - lined steel or certain fluoropolymers. Store it separately from incompatible substances such as bases, oxidizing agents, and reducing agents to prevent reactions.
    Shipping 2,2,2 - Trifluoroacetic Acid is a corrosive chemical. Shipping requires proper packaging in corrosion - resistant containers. It must comply with hazardous materials regulations, with clear labels indicating its nature for safe transportation.
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    2,2,2-Trifluoroacetic Acid
    General Information
    Historical Development
    "Evolution of ditrifluoroacetic acid"
    In the past, organic chemistry was thriving, and many people were committed to the research of new substances. Ditrifluoroacetic acid has emerged, the initial synthesis is difficult, and the yield is quite low.
    However, scholars continue to study the mechanism and improve the process. Over the years, the synthesis method has become more and more refined, and the yield has also increased.
    At present, ditrifluoroacetic acid is widely used in the fields of medicine and materials. Looking at its process, it starts from the very beginning, gathers through the wisdom of the crowd, and finally becomes a useful material. This is the wonder of the evolution of science and technology.
    Product Overview
    Di-, di-, and di- trifluoroacetic acid, with the property
    di-, di-, and di- trifluoroacetic acid, is a commonly used reagent in organic chemistry. Its properties are colorless, pungent odor liquid, with a boiling point of about 70 degrees Celsius and a melting point of about minus 15 degrees Celsius. This substance can be miscible in various organic solvents such as water and ethanol, and is widely used in the field of organic synthesis.
    Because its structure contains three fluorine atoms, it is highly acidic, and is often used as a catalyst or acidic reagent in many chemical reactions. In drug synthesis, it can promote specific reactions and improve the yield and purity of the product.
    In terms of storage, it should be placed in a cool and well-ventilated place, away from fire and heat sources to prevent volatilization and danger. When using it, follow the corresponding operating procedures to ensure safety, as it is corrosive and irritating.
    Physical & Chemical Properties
    "Theory of Matter"
    2,2,2-trifluoroacetic acid has different physical and chemical properties. Looking at its properties, it is a colorless and transparent liquid at room temperature, highly corrosive and pungent. Its melting point is quite low, about -15.4 ° C, and its boiling point is not very high, around 72.4 ° C.
    This substance has good solubility and can be miscible in water and most organic solvents. It has strong chemical activity and significant acidity, far exceeding that of ordinary organic acids. Because of its fluorine-containing atoms, the density distribution of electron clouds changes, and its chemical stability and reaction characteristics are unique. In industry and scientific research, it is often used in many fields such as organic synthesis and catalytic reactions because of its unique physical and chemical properties. It is an important chemical raw material.
    Technical Specifications & Labeling
    "Technical Specifications and Labeling (Commodity Parameters) "
    There is 2,2,2-trifluoroacetic acid now, and its technical specifications are related to the preparation method and purity requirements. The preparation needs to follow a precise process to achieve the specified quality. In terms of purity, it should reach a very high standard, and the impurity content should be minimal.
    As for the label, when declaring the name of this product, mark its main ingredients and content. On the packaging, clearly indicate the parameters of the product, such as density, boiling point and other physical characteristics, and also mark the method of storage and the precautions for use. In this way, the user can know its properties in detail, use it correctly, and ensure that this product can be properly used in various fields.
    Preparation Method
    Preparation of 2,2,2-trifluoroacetic acid
    To prepare 2,2,2-trifluoroacetic acid, the raw materials and production process are the key. The raw materials are selected as the best, and the appropriate fluorine-containing compounds are used as the basis. In the production process, the reaction steps should be detailed.
    First take an appropriate amount of fluorine-containing starting materials, and control them in a specific reactor with precise temperature and pressure. First, through a certain step of reaction, the molecular structure is initially changed. This step needs to be stabilized and the reaction time should not be excessive or insufficient.
    Then, through a series of conversions, with a suitable catalyst, the reaction is promoted to the direction of generating the target product. During the conversion, closely monitor the reaction process and fine-tune the conditions according to changes.
    As for the activation mechanism, when the power of the catalyst is used to lower the reaction energy barrier, the reaction is easy to start and efficient. In this way, through various steps, 2,2,2-trifluoroacetic acid can be obtained.
    Chemical Reactions & Modifications
    On the Chemical Reaction and Modification of 2,2,2-Trifluoroacetic Acid
    Chemists, the science of change. 2,2,2-Trifluoroacetic Acid has unique characteristics. It is often the key agent in the reaction.
    Looking at its reaction, or promoting chemical synthesis, or inducing decomposition, it is all due to its own characteristics. Its strong acidity can activate many substrates and cause reactions to be easy. Such as the genus of nucleophilic substitution, when the substrate encounters it, the activity is greatly increased, and the reaction speed is good.
    As for modification, based on it, specific materials can be made. Chemical modification can change the physical and chemical properties of substances. Or increase its stability, or change its solubility, so it has a wide range of uses.
    Therefore, 2,2,2-trifluoroacetic acid has significant functions in chemical reactions and modifications, and is an indispensable thing in the field of chemistry.
    Synonyms & Product Names
    "The same name and trade name of 2,2,2-trifluoroacetic acid"
    Today there is a chemical substance, the name is 2,2,2-trifluoroacetic acid. The word of the same name is also called trifluoroacetic acid. The two refer to the same. As for the name of the product, it varies according to its nature or its use.
    In the field of Guanfu chemistry, this substance has a wide range of uses. In the industry of organic synthesis, it is often a reagent, which helps to form various reactions. Because of its unique properties, it can make the reaction smooth and the yield is also good. Merchants here, according to their merits, name their products. There are those who call it efficacy, which is called "high-efficiency combined and promoting trifluoroacetic acid"; there are those who call it purity, which is called "high-purity 2,2,2-trifluoroacetic acid". Although the names are different, they are actually all this thing. Therefore, if you want to know the product of this thing, you should carefully examine its name and clarify its essence, so as not to be wrong.
    Safety & Operational Standards
    Specifications for the safety and operation of di-, di-, and trifluoroacetic acid products
    For those with di-, di-, and di- trifluoroacetic acid, it is also a chemical product. Its characteristics are specific, related to safety and operation standards, and must not be ignored.
    Where this object is involved, the first place to put it. When placed in a cool, dry and well-ventilated place, away from fireworks, heat and fire. Cover it with flammability, and if you don't pay attention to it, it may cause harm. Storage utensils must be tightly sealed to prevent leakage.
    When handling, protection is essential. Wear protective clothing, goggles and gloves, and do not let your skin, eyes and eyes contact it. If you accidentally touch it, quickly rinse it with a lot of water, and in severe cases seek medical attention.
    When using it, strictly abide by the procedures. Operate in a well-ventilated place to avoid the accumulation of gas. The utensils used must be clean and intact to ensure a smooth reaction. After use, properly dispose of the residue, and do not discard it at will to avoid polluting the environment.
    Furthermore, know the emergency measures. In the event of a fire, use dry powder and carbon dioxide to extinguish the fire, not water. If it leaks, stop the source first, and then cover it with sand, vermiculite, etc., and take it away.
    In short, the safety and operating standards of di-, di-, and di- trifluoroacetic acid are the principles that users should abide by. By following this standard, we can avoid accidents in the first place, maintain personal safety and the cleanliness of the environment, and make this good use.
    Application Area
    "The application field of 2,2,2-trifluoroacetic acid"
    2,2,2-trifluoroacetic acid is quite useful in various application fields. It can be used in organic synthesis, as a key reagent for many reactions, and helps to create new compounds. In the field of medicine, it is often an important raw material for drug synthesis, or participates in the construction of active ingredients to help the progress of pharmaceutical research and development. In the field of materials science, it also has its application, which can optimize material properties and improve material quality. In the field of analytical chemistry, it can be used as an analytical reagent to assist in the accurate analysis of material composition. Therefore, 2,2,2-trifluoroacetic acid is indispensable in various application fields, and it has a great contribution to promoting the development of related fields.
    Research & Development
    The era of research and creation of trifluoroacetic acid
    Today there is a chemical product, called 2,2,2-trifluoroacetic acid. Its unique nature and wide range of uses. In the field of scientific research, it is an important reagent to help people experiment with accurate results.
    Study its quality and analyze its properties, chemists have worked hard. After many explorations, it has been possible to understand its reaction mechanism and its physical and chemical characteristics. Then seek innovative methods to improve yield and optimize quality.
    With a tough heart, craftsmen have tried countless times. Or improve the process, or find new raw materials, hoping that this product can be more perfect. In the production process, strictly control the details to ensure that the product is pure and excellent.
    Therefore, 2,2,2-trifluoroacetic acid has shown extraordinary effects in scientific research and industry. Looking to the future, we should continue to study and innovate, so that it can bloom more brilliantly in various fields, contribute to the progress of science and technology, the prosperity of industry, and create new chapters.
    Toxicity Research
    Toxicological study
    There is a modern thing, named "2,2,2 - Trifluoroacetic Acid", which is quite commonly used in chemical industry. However, its toxicity cannot be ignored.
    Study this thing, its entry path, either by breathing, or through the skin, or by mistake. After entering the body, it may disturb the ability of the viscera, or disrupt the luck of qi and blood. Tested in animals, it can be seen that its hair falls off, its weight is reduced, and its organs are damaged.
    And this thing is also harmful to the environment. If it is carelessly discarded, it will seep into the soil, pollute and water sources, causing fish and shrimp to die, and vegetation to wither. Therefore, when all karma use it, they must scrutinize its laws in detail, and observe its poison, in order to prevent it from developing, and to ensure the safety of the people and the tranquility of the environment.
    Future Prospects
    "Future Prospects: 2,2,2-Trifluoroacetic Acid Products"
    In today's world, technological advancements, 2,2,2-trifluoroacetic acid products are also limited. Its application in the field of chemical engineering may help the research of new products and make the material properties more excellent. For example, it is used in special products to increase its resistance and wear resistance. In terms of technical aspects, or new research and development, accelerate the synthesis of materials, improve their efficiency, and add more tiles in a step. To ensure one way, or to improve the color industry, the birth of energy consumption, and the environment. This product will definitely be able to bring great colors to many fields, lead to unseen trends, and expand the world.
    Where to Buy 2,2,2-Trifluoroacetic Acid in China?
    As a trusted 2,2,2-Trifluoroacetic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2,2,2-Trifluoroacetic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,2,2-trifluoroacetic acid?
    2% 2C2% 2C2-tribromopropionic acid is also an organic compound. Its main use is quite extensive.
    First, in the field of medicine, it is often used as a raw material for synthetic drugs. Due to its special chemical structure, it can be converted into therapeutic drug ingredients through specific chemical reactions, helping to fight various diseases and maintain human health.
    Second, in agriculture, it also has important applications. It can be made into pesticides to control pests and diseases of crops. It can rely on its own chemical properties, or inhibit the growth and development of pests, or interfere with the reproduction and spread of pathogens, to ensure the robust growth of crops and improve the yield and quality of agricultural products.
    Third, in the field of materials science, 2% 2C2% 2C2-tribromopropionic acid can participate in the synthesis of some polymer materials. After appropriate polymerization, materials can be endowed with special properties such as flame retardancy. In modern society, many places have high requirements for flame retardancy of materials. The flame retardant materials made of this compound can be widely used in construction, electronics and other industries to enhance the safety of places and reduce the risk of fire.
    Fourth, in organic synthetic chemistry, 2% 2C2% 2C2-tribromopropionic acid is often used as a key intermediate. Chemists can build more complex organic molecular structures by performing various functional group conversion reactions on them, providing a foundation for the research and development of new organic compounds and promoting the continuous development and innovation in the field of organic chemistry.
    What are the effects of 2,2,2-trifluoroacetic acid on the environment?
    2% 2C2% 2C2-trifluoroacetic acid, this substance is highly corrosive and irritating, and has a significant impact on the environment. It is highly acidic and discharged into natural water bodies, which can cause a sudden drop in the pH value of water bodies and endanger aquatic organisms. If a large amount of this substance is discharged into streams, it will cause drastic changes in the living environment of fish and shrimp and other organisms, or cause their death, and destroy the water ecological balance.
    And its chemical stability is high, difficult to degrade naturally, and easy to accumulate in the environment. If this substance exists in the soil, it will change the physical and chemical properties of the soil, affect the activities of soil microorganisms, hinder the absorption of nutrients by plants, inhibit the growth of vegetation, and reduce land productivity.
    In the atmosphere, 2% 2C2% 2C2-trifluoroacetic acid volatilizes or enhances the acidity of the atmosphere, causing harm such as acid rain. Acid rain falls on forests, erodes trees, affects photosynthesis, causes slow growth and even death of trees; falls on ancient buildings, corrodes building materials, such as marble, etc., causing damage to ancient sites.
    Therefore, when producing and using 2% 2C2% 2C2-trifluoroacetic acid, strict control is required, and effective treatment measures are taken to reduce its negative impact on the environment and protect ecological safety.
    What are the precautions for storing and transporting 2,2,2-trifluoroacetic acid?
    For those with 2% 2C2% 2C2-trihydroxybutyric acid, there are things to be paid attention to when they are hidden and transported.
    When hiding, the first thing to pay attention to is the environment in which they are located. It is necessary to choose a cool and dry place to avoid the exposure of sunlight and the damp moisture. If you cover this thing with delicate nature, it will be easy to melt when heated, and it will change its quality when wet. If you hide it in a warm and humid place, it will not only damage its nature, but also be afraid of danger.
    Furthermore, its equipment must also be selected carefully. It is advisable to use a strong and dense equipment to prevent air from entering and sundries from invading. If there are gaps in the equipment, it is easy to cause it to melt when the gas enters, and if the sundries enter, it will be messed up. It is not good.
    As for the transportation, the operator must be cautious and careful. Wear protective gear, such as gloves and masks, to avoid their contact with the body and the mouth. Because of its strong nature, the contact may hurt the skin, and the mouth will damage the viscera.
    When the transportation is carried out, it should also be steady and slow to avoid the drama of bumps. If you walk on a rough road, the vibration is too much, and you are afraid that the device will break and the object will leak, and there will be no great disaster. And the companions must also understand their nature, know their risks, and be able to respond quickly in case of changes, so as to keep them safe and safe.
    In short, the transportation of 2% 2C2% 2C2-trihydroxybutyric acid is related to the integrity of material nature and the safety of everyone. It must be handled with respect and care, and there must be no slack.
    What are the physical and chemical properties of 2,2,2-trifluoroacetic acid?
    2% 2C2% 2C2 -trifluoroacetic acid, is an organic compound. Its physical and chemical properties are as follows:
    Physical properties
    1. ** Properties **: Colorless volatile fuming liquid, with a pungent odor, similar to vinegar, and pungent smell. It easily forms acid mist in the air, which can cause respiratory discomfort, so caution is required when operating.
    2. ** Boiling point **: about 72.4 ° C, relatively low, volatile when heated. This characteristic makes it easy to separate from the mixture under heating or decompression conditions, which is quite practical in the post-processing of organic synthesis.
    3. ** Melting point **: -15.2 ° C, liquid at room temperature, solidified at low temperature.
    4. ** Solubility **: It is miscible with water, ethanol, ether and other organic solvents. Due to its strong polarity, it can form hydrogen bonds or other intermolecular forces with many polar molecules, resulting in excellent solubility. It can dissolve many organic and inorganic compounds as a solvent, providing a homogeneous reaction environment for organic reactions.
    5. ** Density **: 1.5351g/mL, larger than water, and will sink to the bottom when mixed with water.
    Chemical properties
    1. ** Acidic **: It is a strong acid, and its acidity far exceeds that of common organic acids such as acetic acid. Its pKa value is about -0.25, and it is almost completely ionized in aqueous solution. It can react rapidly with alkalis to form corresponding salts and water, and can also cause some weak acid salts to undergo acid hydrolysis reactions to release weak acids. In organic synthesis, it is often used as an acid catalyst to promote reactions such as esterification, etherification, and rearrangement.
    2. ** Oxidation **: Although it is not a typical strong oxidizer, it can exhibit certain oxidizing properties under specific conditions. When reacting with some organic compounds with reducing properties, it may be reduced by itself, but this property is relatively rarely used.
    3. ** Nucleophilic Substitution Reaction **: In the molecule, the - CF 🥰 group has a strong electron-absorbing ability, which enhances the positive electricity of the carboxyl carbon atom and is vulnerable to attack by nucleophilic reagents. Nucleophilic substitution reactions occur, such as reacting with alcohols to form esters and reacting with amines to form amides. It is an important method for preparing fluorine-containing organic compounds.
    4. ** Deprotecting Groups **: It is widely used in the field of organic synthesis to remove specific protecting groups. Due to its strong acidity and high selectivity for certain protecting groups, the protecting groups can be efficiently removed without affecting other parts of the molecule, so that the protected functional groups can be restored to activity.
    What are the preparation methods of 2,2,2-trifluoroacetic acid?
    2% 2C2% 2C2-tribromopropionic acid is an organic compound, and there are several common methods for its preparation.
    First, acrylic acid is used as raw material and obtained by bromination reaction. Put acrylic acid in a suitable reaction vessel, add an appropriate amount of catalyst, such as benzoyl peroxide, etc. Then, slowly add bromine dropwise, and under specific temperature and stirring conditions, make the two fully react. The double bond of acrylic acid is added to bromine to generate 2% 2C2% 2C2-tribromopropionic acid. This reaction needs to be controlled at the reaction temperature to prevent side reactions from occurring, and bromine is highly corrosive and volatile. The operation process must be carried out with caution and in a well-ventilated environment.
    Second, diethyl malonate is used as the starting material. First, diethyl malonate interacts with alkaline substances such as sodium alcohol to form the corresponding sodium salt. Then, bromoalkane is added for alkylation reaction. Then, the reaction product is hydrolyzed and decarboxylated to obtain 2% 2C2% 2C2-tribromopropionic acid. This route has relatively many steps, but the raw materials are more common, and the reaction conditions of each step are easier to control.
    Third, 2-bromopropionic acid is used as the raw material. 2-Bromopropionic acid is further brominated with a brominating agent, such as N-bromosuccinimide (NBS), in an appropriate solvent, under the action of light or initiator. By precisely controlling the reaction conditions, such as reaction time, temperature, and ratio of reactants, bromine atoms can be gradually replaced by hydrogen atoms at specific locations in 2-bromopropionic acid molecules to obtain 2% 2C2% 2C2-tribromopropionic acid. This method requires high reaction conditions, and each parameter needs to be carefully adjusted to ensure the purity and yield of the product.